Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1995-05-04
1996-10-08
Owens, Amelia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 79, 514 82, 514114, 546 22, 546 23, 548113, 548413, A61K 31675, A61K 3166
Patent
active
055631282
ABSTRACT:
This invention relates to a class of novel phosphonate derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis aryl cycloalkylamino and azacycloalkyl phosphonates. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
REFERENCES:
patent: 5441946 (1995-08-01), Pauls et al.
Amin Dilip V.
Choi Yong-Mi
Pauls Henry W.
Nicholson James A.
Owens Amelia
Parker III Raymond S.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Savitzky Martin F.
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