Phosphonate-containing pseudopeptides of the hydroxyethylamine a

Details Phosphonate-containing pseudopeptides of the hydroxyethylamine a Phosphonate-containing pseudopeptides of the hydroxyethylamine a

1991-08-15

1994-11-15

Rotman, Alan L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Tripeptides, e.g., tripeptide thyroliberin , etc.

546 22, 546 23, 548111, C07F 958, C07F 960, C07F 9572

Patent

active

053649311

ABSTRACT:
The invention relates to phosphonate-containing pseudopeptides of the hydroxyethylamine and norstatin type, to new oxirane- and thiirane-containing pseudopeptides as intermediates, to processes for their preparation and to their use as retroviral agents.

REFERENCES:
patent: 4186268 (1980-01-01), Petrillo, Jr.
patent: 4599198 (1986-07-01), Hoover
J. Med. Chem. 31, 1839 (1988).
J. R. Lully et al., J. Org. Chem. 52, 1487 (1987).
Journal Medicinal Chemistry, vol. 31, No. 3, 1988, pp. 532-539.

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