Phosphonamide ACAT inhibitors

Details Phosphonamide ACAT inhibitors Phosphonamide ACAT inhibitors

1998-06-09

2000-01-25

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514109, 514114, 514119, 514137, 514824, A61K 3166

Patent

active

060179058

ABSTRACT:
The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein Ar and Ar.sup.1 are each independently selected from unsubstituted or substituted phenyl which substituents are from 1-5 in number and are each independently selected from alkyl, alkoxy, hydroxy, halogen, nitro, trifluoromethyl, COOH, and COOalkyl;

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J Chem Soc Perkins Trans 1, Eli Breuer, (12) p. 3263-3269, Dec. 1990.
Beilstein, Brn=285976, Abst of J Gen Chem USSR, Derkatsch, 35, pp. 1019, 1965.
CA:90:87579, abst of "Alkyl esters of acylamidophosphoric and acylamidoalkyl(aryl)phosphonic acids", Zagnibeda, Khim Yekhnol 101 pp. 21-24, 1978.

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