Phosphonamide ACAT inhibitors

Details Phosphonamide ACAT inhibitors Phosphonamide ACAT inhibitors

1997-06-24

1998-09-15

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514110, 514114, 558195, 558199, 558178, A61K 3166

Patent

active

058078460

ABSTRACT:
The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein Ar and Ar.sup.1 are each independently selected from unsubstituted or substituted phenyl which substituents are from 1-5 in number and are each independently selected from alkyl, alkoxy, hydroxy, halogen, nitro, trifluoromethyl, COOH, and COOalkyl;

REFERENCES:
patent: 4627870 (1986-12-01), Nagubandi
patent: 4849488 (1989-07-01), Starzewski et al.
patent: 5013854 (1991-05-01), Bunnell
patent: 5084568 (1992-01-01), Bunnell
patent: 5208224 (1993-05-01), Bolton
patent: 5412097 (1995-05-01), Chakravarty et al.
patent: 5494983 (1996-02-01), Reetz
J Chem Soc Perkins Trans 1, Eli Breuer, (12) pp. 3263-3269, Dec. 1990.
Beilstein, Brn=285976, Abst of J Gen Chem USSR, Derkatsch, 35, p. 1019, 1965.
CA:90:87579, abst of "Alkyl esters of acylamidophosphoric and acylamidoalkyl(aryl)phosphonic acids", Zagnibeda, Khim Yekhnol 101 pp. 21-24, 1978.

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