Phospholipid transfer protein (PLTP) and cholestoral metabolism

Details Phospholipid transfer protein (PLTP) and cholestoral metabolism Phospholipid transfer protein (PLTP) and cholestoral metabolism

2006-07-18

2006-07-18

Badio, Barbara P. (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S824000

Reexamination Certificate

active

07078411

ABSTRACT:
A method for controlling cholesterol metabolism in a host, a screening assay for agents that can control cholesterol metabolism, and the agents that may be identified are practiced and determined in relation to the expression of PLTP in HepG2 cells and a clone from these cells, designated HepG2/PLTPpLuc. Particular agents that are covered comprise camptothecin, topotecan, derivatives thereof, metabolic byproducts thereof and small molecule mimics thereof.

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