Phospholipid-saccharide conjugates

Details Phospholipid-saccharide conjugates Phospholipid-saccharide conjugates

1993-03-12

1994-10-11

Lilling, Herbert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 74, 536 41, 536124, C12P 1944, C07H 1500, C07G 300

Patent

active

053548531

ABSTRACT:
Novel phospholipid-saccharide conjugates are produced by the reaction of a phospholipid derivative and an activated saccharide. The resulting conjugates can be used to make liposomes which are target-specific or resistant to degradation in vivo.

REFERENCES:
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Gurr et al Biochem J. (1968) 108, 211.
ASTN ABS of CA 119(15):158396v Ri et al JP 05132496 May, 28, 1993.
P. W. Tang, et al. "Novel Approach to Study of the Antigenicities and Receptor Functions of Carbohydrate Chains of Glycoproteins", Biochemical and Biophysical Research Communications, 132, No. 2: 474-480 (1985).
Haensler, et al. "Influence of the galactosyl ligand structure on the interaction of galaosylated liposomes with mouse peritoneal macrophages", Glycoconjugate Journal, 8: 116-124 (1991).
Weissig, et al. "Covalent coupling of sugars to liposomes", Biochimica et Biophysica Acta, 1003: 54-57 (1989).
Singh, et al. "Phosphatidylhydroxyalkanols as Versatile Intermediates in the Synthesis of Headgroup Modified Diacetylenic Phospholipids", Synthetic Communications, 22(16): 2293-2304 (1992).

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