Phospholipid drug derivatives

Details Phospholipid drug derivatives Phospholipid drug derivatives

1997-03-31

1998-11-03

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

514177, 514420, 514422, 514533, A61K 4744

Patent

active

058304320

ABSTRACT:
Disclosed herein are methods for increasing the aqueous solubility and bio-availability of bioactive agents having a free carboxyl group by conjugating the agent to one or more amino alcohol phosphocholine moieties selected from the group consisting of sphingosylphosphocholine, 2-aminoglycerol phosphocholine, serine-phosphocholine, threonine phosphocholine, tyrosine-phosphocholine, aminoethanol-phosphocholine or hydroxyproline-phosphocholine. Also disclosed herein are pharmaceutical formulations comprising the agents produced by the method.

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