Phospholipid derivatives

Details Phospholipid derivatives Phospholipid derivatives

1986-11-21

1988-10-18

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558169, C07F 910

Patent

active

047789123

ABSTRACT:
Phospholipid derivatives of the formula: ##STR1## wherein R.sup.1 is a higher alkyl, acylmethyl or alkylcarbamoyl group which may be substituted by cycloalkyl; R.sup.2 is a lower alkyl which may be substituted by carboxy, formyl or lower acyl, a carbamoyl or thiocarbamoyl group which is substituted by lower alkyl, or an acetoacetyl group; R.sup.3, R.sup.4 and R.sup.5 are independently hydrogen or lower alkyl, or ##STR2## represents a cyclic ammonio group; and n represents an integer of 8 to 14, and salts thereof have antitumor activity.

REFERENCES:
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patent: 4382035 (1983-05-01), Eibl
patent: 4426330 (1984-01-01), Sears
patent: 4534899 (1985-08-01), Sears
patent: 4640913 (1987-02-01), Wissner et al.
Tokumura et al., J. Biol. Chem., vol. 260, No. 23, 1985, pp. 12710-12714.
Wissner et al., J. Med. Chem., vol. 29, No. 3, 1986, pp. 328-333.

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