Phospholipid delivery vehicle for aqueous-insoluble active ingre

Details Phospholipid delivery vehicle for aqueous-insoluble active ingre Phospholipid delivery vehicle for aqueous-insoluble active ingre

1989-05-01

1990-10-16

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 43, 424420, 4284022, 514245, 514965, A61K 9133, A61K 4505, B01J 1302

Patent

active

049633635

ABSTRACT:
Compositions comprising phospholipid-encapsulated vesicles of active ingredient and triglyceride are described. In a preferred embodiment the vesicles are composed of a hexamethylmelamine active ingredient, with trilaurin or trimyristin as the triglyceride and a mixture of distearoylphosphatidylcholine, distearoylphosphatidylglycerol and cholesterol in the phospholipid outer layer. Preferably the molar ratios of active ingredient: triglyceride: DSPC: CHOL:DSPG will be from about 1:4:2:1:0 to about 1:4:1:1:1. Glycerol may be added to the carrier phase to reduce agglomeration. The composition may be used to deliver otherwise aqueous-insoluble agents to humans or animals to treat, for example, tumors.

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patent: 4621023 (1986-11-01), Redziniak et al.
patent: 4708861 (1987-11-01), Popescu et al.
patent: 4725442 (1988-02-01), Haynes

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