Phospholipid-containing composition, a process for its preparati

Details Phospholipid-containing composition, a process for its preparati Phospholipid-containing composition, a process for its preparati

1990-06-19

1992-05-19

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424450, 514 78, 514777, 514970, 514974, A61K 920, A23J 700

Patent

active

051149281

DESCRIPTION:

BRIEF SUMMARY
DESCRIPTION

The invention relates to new phospholipid-containing compositions which, in addition to the corresponding phospholipids, contain Palatinit as a solidifying agent and if appropriate one or more auxiliaries, and a process for their preparation. The composition can be used as a solid oral presentation form.
Phospholipids occur widely in nature and can be obtained from animal and vegetable materials. The main sources are eggs (egg lecithin) and soya (soya lecithin), oil seeds and oil fruits, such as, for example, coconutcopra, palm kernels, groundnuts, rape, sunflower kernels, oil palms and olives. The phospholipids are predominantly obtained as a by-product in the production of vegetable oils. During this, a viscous mass is obtained by the so-called desliming of the vegetable oils, which is effected by passing small amounts of steam or water into the crude oil at elevated temperatures. This so-called lecithin slime has a varying composition, depending on its origin:
The commercially available crude lecithin is obtained by drying the lecithin slime in an evaporator at elevated temperatures (80.degree. C.) over a relatively long period of time (from 6-12 hours) or at 100.degree. C. in a thin film evaporator with a shorter residence time.
The most important crude lecithin is soya lecithin, which, after drying, contains about 52% by weight of phospholipids, 35% by weight of oils and fatty acids, 10% by weight of glycolipids and sugars, 2% by weight of non-hydrolysable portions and 1% by weight of water.
The so-called de-oiled phospholipids (or de-oiled crude lecithin which contains only small amounts of oil and other concomitant lipids) are obtained by treatment with corresponding solvents, for example acetone. The lecithin fractions obtained have varying phospholipid compositions depending on their origin:


Soya Lecithin



Egg Lecithin



Rape Lecithin



Saflower Lecithin

The individual lecithins can also be purified by known processes and the corresponding phospholipids can be separated into the individual constituents, such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol, lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylserine or lysophosphatidylglycerol, or olefinic mixtures can be prepared.
The phospholipid mixtures of very different composition, starting from wet lecithin slime, crude lecithin and de-oiled lecithin up to phospholipid mixtures of defined composition or even pure phospholipids, such as, for example, phosphatidylcholine, have physical properties which deviate very widely from one another. The phospholipid mixtures have a very different consistency from liquid to viscous-plastic. The plasticity of the lecithin increases with its degree of purity, that is to say as the phosphatidylcholine content increases and the oil content decreases.
Since lecithin and, to an increasing degree, highly pure lecithin are available, as is known, as a very highly viscous, paste-like composition, working already presents considerable difficulties because of the viscosity of the lecithin. The lecithin is difficult to meter, and because of its viscous consistency remains stuck to the equipment with which it comes into contact, so that the residues which remain require frequent and expensive cleaning of the equipment.
It is therefore often necessary to make do with preparing viscous or pasty preparations for the corresponding use from the crude lecithin by addition of auxiliaries.
If pure lecithin or particularly highly pure lecithin is used, the problem that the increasing purity of the lecithin results in the lecithin becoming increasingly sparingly soluble arises in particular.
The hygroscopic nature of the highly pure lecithin which renders mixing or coating of the highly pure lecithin with fat-like waxy substances practically impossible is a further hindrance.
Attempts have therefore often been made to convert lecithin into forms which allow easier processing.
Thus, U.S. Pat. No. 2,057,695 describes a process

REFERENCES:
patent: 3012888 (1961-12-01), Davis
Chemical Abstracts, vol. 109, No. 19, Abstract 169028v, Nov. 7, 1988.
Chemical Abstracts, vol. 104, No. 10, Abstract 74837r, Mar. 10, 1986.

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