Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1985-07-01
1988-08-02
Sutto, Anton H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
260403, A61K 31685, C07F 910
Patent
active
047614048
ABSTRACT:
There are disclosed phospholipid analogs which are useful as PAF synthesis inhibitors. These compounds inhibit PAF (platelet-activating factor) biosynthesis and are thereby useful in the treatment of various diseases or disorders mediated by the PAF such as, for example, pain, fever, inflammation, cardiovascular disorder, asthma, lung edema, allergic disorders, skin diseases, psoriasis, and adult respiratory distress syndrome.
REFERENCES:
patent: 3985875 (1976-10-01), Hayashi et al.
patent: 4221732 (1980-09-01), Oette et al.
Chandrakumar et al., "Biochimica et Biophysica Acta", vol. 711, (1982), pp. 357-360.
Bugianesi Robert L.
Ponpipom Mitree M.
Rupprecht Kathleen M.
Cheng Theresa Y.
Merck & Co. , Inc.
Sudol Michael C.
Sutto Anton H.
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