Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1997-08-13
2000-03-28
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4352523, 4353201, 536 232, 536 235, 536 236, 530350, C12N 920, C12N 120, C12N 1500, C07H 2104
Patent
active
060430737
ABSTRACT:
Provided are novel phospholipase D DNA and amino acid sequences. The sequences are useful in methods and compositions for identifying phospholipase D mediator molecules which are in turn useful in therapeutic pharmacuetical compositions for treating rheumatoid arthritis, psoriasis, ulcerative colitis, in wound healing and for treating other diseases or conditions characterized by exhibition of an inflammatory response or in the treatment of cancer and other diseases characterized by pathogenic mitogenicity.
REFERENCES:
patent: 5747327 (1998-05-01), Ueki et al.
Hammond et al., "Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family" Dec. 1995, pp 29640-29643, vol. 270 No. 50 The Journal of Biological Chemistry.
Ribbes et al., "Expressed Sequence Tags Identify Human Isologs of the ARF-Dependent Phospholipase D" 1996, Biochemicah and Biophysical Research Communications 224, pp 206-211, Art. No. 1008.
Ktistakis et al., "Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A" May 1995, Cell Biology vol. 92, pp 4952-4956.
Hammond et al., "Characterization of Two Alternately Spliced Forms of Phospholipase D1" Feb. 1997 The Journal of Biological Chemistry, vol. 272, No. 6, pp. 3860-3868.
Colley et al., "Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization" Current Biology, vol. 7 No. 3, Mar. 1997.
Engebrecht Joanne
Frohman Michael A.
Morris Andrew J.
Achutamurthy Ponnathapu
Cserr Luann
Giotta Gregory
Saidha Tekchand
The Research Foundation of the State University of New York
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