Phospholipase A2 inhibitors

Details Phospholipase A2 inhibitors Phospholipase A2 inhibitors

1990-04-26

1991-12-03

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548437, 548444, 568308, 568326, 568328, C07D27504, C07D20982, C07D 49213, C07D 49115

Patent

active

050702076

ABSTRACT:
There is disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma, psoriasis, inflammatory bowel disease and inflammation in mammals which comprises administering to a mammal so afflicted an effective amount of a compound having the formula: ##STR1## wherein Z is a group having the formula ##STR2## R.sup.1 and R.sup.2 are each, independently, hydrogen or lower alkyl; R.sup.3 and R.sup.4 are each, independently, hydrogen, alkyl of 1-20 carbon atoms, halo, halo lower alkyl, halo lower alkoxy, lower alkoxy, halo lower alkylsulfonyl, nitro or trifluoromethyl, where at least one of R.sup.3 and R.sup.4 is other than hydrogen;

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Copy of Chemical Abstracts Structural Search Output with Cross Reference to R and S above.
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