Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1985-08-23
1990-09-25
Elmore, Carolyn S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
260403, 514928, A61K 3166, C07F 111
Patent
active
049593579
ABSTRACT:
Potent, specific inhibitors of phospholipase A.sub.2 are disclosed which are compounds of the formula: ##STR1## wherein A is R.sub.1 CO.sub.2 or OH, B is R.sub.2 CO.sub.2 or OH, D is R.sub.3 CO.sub.2 or OH and C is R.sub.4 CO.sub.2 ; and wherein R.sub.1, R.sub.2, and R.sub.3 and R.sub.4 are each C.sub.10 -C.sub.30 alkyl groups comprising from about 0-3 double bonds.
REFERENCES:
patent: 3962292 (1976-06-01), Szuhaj et al.
Eaton et al., J. Org. Chem., vol. 37, No. 12, (1972), pp. 1947-1950.
Torregrossa et al., Chemical Abstracts 87: 113704x, (1977).
Cable et al., Chemical Abstracts 89: 1991y, (1978).
R. E. Torregrossa et al., J. of Bact., 131(2) (1977), 493-498.
M. B. Cable et al., Proc. Natl Acad. Sci., 75(3) (1978), 1227-1231.
Pfeiffer Douglas R.
Reers Martin
Elmore Carolyn S.
Regents of the University of Minnesota
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