Phospholipase A2 conjugated to a tarqeting moiety and their ther

Details Phospholipase A2 conjugated to a tarqeting moiety and their ther Phospholipase A2 conjugated to a tarqeting moiety and their ther

1991-04-03

1992-07-14

Nucker, Christine

Drug, bio-affecting and body treating compositions

Lymphokine

424 943, 435 76, 435188, 435198, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 21, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530389, 530399, 530402, 530409, 5303917, A61K 3944, A61K 3724, C07K 1702, C12N 920

Patent

active

051301300

ABSTRACT:
The present invention relates to a basic protein called phospholipase A2 (PLA2), isolated from the venom of a snake of the family Elapidae, especially of a Naja snake and more particularly Naja nigricollis and/or Naja mossambica pallida, to the fragments and derivatives of the said protein, to their methods of preparation, to pharmaceutical compositions which can be used in human and/or veterinary medicine, and to diagnostic agents in which the said protein and/or its derivatives and/or its fragments are present.
The said protein comprises 118 amino acids, its molecular weight is of the order of 13,300 Daltons and its isoelectric point is of the order of 8.6.
The derivatives of the said protein are modified at one of the histidines by fixation of an alkyl group of the formula R--CH.sub.2 --X.
Application to the detection of tumoral cells are discussed.

REFERENCES:
patent: 5045462 (1991-09-01), Menez et al.
Dennis (1983) in The Enzymes (Boyer P.D ed) pp. 307-353, Academic Press, N.Y. vol. 16.
Fryklund et al (1975) Biochemistry 14(13): 2865-2871.
Halpert et al (1976) FEBS Lett, 61(1):72-76.
Joubert (1977) Biochim Biophys Acta 493: 216-227.
Joubert et al (1980) Eur. J. Biochem. 112:493-499.
Pir (IntelliGenetics) file printout on Joubert et al (1980).
Rudinger in Peptide Hormones (Parsons J. A. ed) 1976 pp. 1-7 Univ. Panl Press, Baltimore.
Volwerk et al (1974) Biochemistry 13(7):1446-1454.

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