Phospholipase A.sub.2 inhibitor

Details Phospholipase A.sub.2 inhibitor Phospholipase A.sub.2 inhibitor

1995-12-13

1997-01-28

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

549393, 549305, 560 11, 560 18, 560 57, 560 64, 560 65, 560 72, 560 73, 560 84, 560 85, 560 86, C07C 6976

Patent

active

055979432

ABSTRACT:
The present invention relates to the new thielocin derivatives, which exhibit phospholipase A.sub.2 inhibitory activity of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are independently hydrogen, lower alkyl, lower alkoxy, hydroxy, or halogen;

REFERENCES:
patent: 3859307 (1975-01-01), Carr et al.
Yoshida et al., The Journal of Antibiotics, vol. 44, No. 12, Dec., 1991, pp. 1467-1470.
Yoshida et al., Chemical Abstracts, vol. 117, No. 17, 26 Oct., 1992 Abstract No. 169572h JP-A-4 159 251.
Yoshida et al., Chemical Abstracts, vol. 117, No. 21, 23 Nov., 1992 Abstract No. 210731x JP-A-4 117 346.

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