Phospholipase A.sub.2 -inhibiting peptides

Details Phospholipase A.sub.2 -inhibiting peptides Phospholipase A.sub.2 -inhibiting peptides

1989-01-26

1990-01-23

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530324, 530325, C07K 708

Patent

active

048959316

ABSTRACT:
Disclosed are peptides which have amino acid sequences consisting of 15 to 26 amino acid constituents and have phospholipase A.sub.2 -inhibiting activity.

REFERENCES:
patent: 4624852 (1986-11-01), Wurtman
patent: 4737489 (1988-04-01), Wurtman
patent: 4775665 (1988-10-01), Wurtman
patent: 4778304 (1988-11-01), Marshall et al.
Wallner, et al., "Cloning and Expression of Human Lipocortin, A Phospholipase A.sub.2 Inhibitor with Potential Anti--Inflammatory Activity", Nature, 320, 77, (1986).
Huang, et al., "Purification and Characterization of Proteolytic Fragments of Lipocortin I That Inhibit Phospholipase A.sub.2 ", J. Biol. Chem., 262, 7639, (1987).

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