Phospholipase A.sub.2 inhibiting compositions and their use

Details Phospholipase A.sub.2 inhibiting compositions and their use Phospholipase A.sub.2 inhibiting compositions and their use

1988-10-21

1991-11-12

Doll, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514781, A61K 3764

Patent

active

050648179

ABSTRACT:
Inhibitors of phospholipase A.sub.2 activity at the cell-surface membrane whose molecular structure comprises a cell-permeable PLA.sub.2 -inhibitor moiety covalently bonded directly or indirectly to a physiologically acceptable carrier moiety which is effective to inhibit cell internalization of the cell-permeable PLA.sub.2 -inhibitor moiety, with the proviso that phosphatidylserine is not bonded indirectly via divalent dodecanedioyl to dextrane hydrazide.

REFERENCES:
patent: 3959080 (1976-05-01), Orth
Blackwell et al., Brt. Med. Bull. (1983), vol. 39, No. 3, pp. 260-264.
Yedgar et al., Febs, vol. 200, No. 1 (1986) pp. 165-168.
Wallach et al., Biochemical Pharmacology (1983), vol. 30, No. 11, pp. 131324.

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