Phospholipase A.sub.2 expressing transgenic animals

Details Phospholipase A.sub.2 expressing transgenic animals Phospholipase A.sub.2 expressing transgenic animals

1994-08-09

1997-04-29

Campell, Bruce R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 424 91, 424 92, 4351723, C12N 500, C12N 1500, G01N 3348

Patent

active

056251254

ABSTRACT:
The present invention concerns transgenic animals that express an abnormaly high level of phospholipase A.sub.2 in their serum, liver, lung, kidney and skin. More particularly rats and mice expressing human non-pancreatic, low molecular weight phospholipase A.sub.2 are disclosed. Although transfected with a normal human gene, the animals develop a variety of pathological signs and produce the enzyme ectopically. The animals of the invention are useful for the testing of compounds to determine whether the compounds possess in vivo activity as phospholipase inhibitors or antagonists suitable for pharmacolgic use.

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