Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1994-08-09
1997-04-29
Campell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 424 91, 424 92, 4351723, C12N 500, C12N 1500, G01N 3348
Patent
active
056251254
ABSTRACT:
The present invention concerns transgenic animals that express an abnormaly high level of phospholipase A.sub.2 in their serum, liver, lung, kidney and skin. More particularly rats and mice expressing human non-pancreatic, low molecular weight phospholipase A.sub.2 are disclosed. Although transfected with a normal human gene, the animals develop a variety of pathological signs and produce the enzyme ectopically. The animals of the invention are useful for the testing of compounds to determine whether the compounds possess in vivo activity as phospholipase inhibitors or antagonists suitable for pharmacolgic use.
REFERENCES:
Kramer et al (1989) J Biol Chem 264: 5768-5775.
Merlino (1991) FASEB J 5: 2996-3001.
Bereziat et al (1990) J Lipid Mediators 2:159-172.
Strojek et al (1988) Genetic Engineering: Principles and Methods 10: 221-246.
Lang, R.A., et al., 1987, Cell 51:675-686.
Shull, M.M., et al., 1992, Nature 359:693-699.
Turksen, K., et al., 1992, Proc. Natl. Acad. Sci. 89:5068-72.
Vassar, R. & Fuchs, E., 1991, Genes & Development 5:714-727.
Keffer, J., et al., 1991, EMBO J. 10:4025-31.
Tepper, R.I., et al., 1990, Cell 62:457-677.
Lewis, D.B., et al., 1992, J. Bone & Min. Res. 7:(51) PS97.
Dent, L.A., 1990, J. Exp. Med. 172:1425.
Wogensen, L., et al., 1994, J. Interferon Res. 14:111-114.
Taverne, J., 1993, Int. J. Exp. Path. 74:525-546.
J. Cell Biochem Suppl., #17, Part B, 1993, p. 92, Abstract E329.
Toyonaga, T., et al., 1994, Proc. Natl. Acad. Sci. USA, 91:614-618.
Taverne, J., 1994, Parasitology Today, vol. 10, No. 7, pp. 258-262.
J. Cell Biochem Suppl., #18, Part A, 1994, p. 283, Abstract E303.
The Journal of Investigative Dermatology, vol. 102, #4, 1994, p. 556, Abstract 195.
Bennett C. Frank
Grass David S.
Swanson Mark E.
Campell Bruce R.
DNX Biotherapeutics
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