Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2003-01-17
2008-09-09
Saidha, Tekchand (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S018000, C435S006120, C536S023200, C536S023500, C536S024300, C536S024310
Reexamination Certificate
active
07422887
ABSTRACT:
To provide a novel phospholipase A2(PLA2) associated with psoriasis, a nucleic acid encoding the same, a method for characterizing, identifying or screening an inhibitor for the PLA2or a medicament; and a novel method for diagnosis or examination of psoriasis or the like. A polypeptide having the amino acid sequence shown in SEQ ID NO: 9, a conservative substitution variant thereof, a naturally occurring allelic variant thereof, or the like. A nucleic acid encoding the above-mentioned polypeptide, a complement thereof or the like. A method for characterizing, identifying or screening an inhibitor for the PLA2or a medicament, using the above-mentioned polypeptide. An examination method for psoriasis, characterized by assaying an expression level of a gene consisting of the above-mentioned nucleic acid or the like.
REFERENCES:
patent: 6025178 (2000-02-01), Choin et al.
patent: 6287838 (2001-09-01), Kriz et al.
patent: WO 02/04490 (2002-01-01), None
patent: WO 02/31162 (2002-04-01), None
Sequence alignment of SEQ ID No. 8 with Accession No. AD36478; Apr. 18, 2002.
Sequence aligmnment of SEQ ID No. 9 with Accession No. AAE22843; Apr. 18, 2002.
Sequence alignment of SEQ ID No. 8 with Accession No. ABA94700; Jan. 17, 2002.
Sequence alignment of SEQ ID No. 9 with SEQ ID No. 6 of US 20040029136A1, Feb. 12, 2004.
Chiba H. et al., “Cloning of a Gene for a Novel Epithelium-specific Cytosolic Phospholipase A2, cPLA2ō, Induced in Psoriatic Skin”, (Mar. 26, 2004), The Journal of Biological Chemistry, vol. 279, No. 13, pp. 12890-12897.
Clark J. D. et al., “A Novel Arachidonic Acid-Selective Cytosolic PLA2Contains a Ca2+-Dependent Translocation Domain with Homology to PKC and GAP”, (Jun. 14, 1991), Cell, vol. 65, pp. 1043-1051.
Clark J.D. et al., GenBank Ac. No. M72393, sequence list, May 23, 1996.
Pickard R.T. et al., “Molecular Cloning of Two New Human Paralogs of 85-kDa Cytosolic Phospholipase A2”, (Mar. 26, 1999), The Journal of Biological Chemistry, vol. 274, No. 13, pp. 8823-8831.
Pickard R.T., GenBank Ac. No. AF065215, sequence list, Mar. 23, 1999.
Song C. et al., “Molecular Characterization of Cytosolic Phospholipase A2-β”, (Jun. 11, 1999), The Journal of Biological Chemistry, vol. 274, No. 24, pp. 17063-17067.
Underwood K.W. et al., “A Novel Calcium-independent Phospholipase A2, cPLA2-γ, That Is Prenylated and Contains Homology to cPLA2”, (Aug. 21, 1998), The Journal of Biological Chemistry, vol. 273, No. 34, pp. 21926-21932.
Underwood K.W. et al., GenBank AF058921, sequence list, Aug. 26, 1998.
Chiba Hiroaki
Imai Yuji
Wakimoto Koji
Browdy and Neimark PLLC
Mitsubishi Tanabe Pharma Corporation
Saidha Tekchand
Walicka Malgorzata A
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