Phosphole derivatives complexed with metals, and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S017100, C546S002000

Reexamination Certificate

active

07923434

ABSTRACT:
The invention concerns pharmaceutical compositions comprising as active compound at least one compound of general formula (A), wherein: M represents a metal atom, and their uses in particular for preventing or treating pathologies associated with an excess activity of glutathion reductase and/or thioredoxin reductase.

REFERENCES:
patent: WO 01/77121 (2001-10-01), None
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Hay, Caroline et al., Chemistry, a European Journal, “Phosphole-Containing Pi-Conjugated Systems: From Model Molecules to Polymer Films on Electrodes” (2001), vol. 7, issue 19, pp. 4222-4236.
Tetrahydrofuran available at http://www.lyondellbasell.com/Products/ByCategory/basic-chemicals/PerformanceChemicalsAndSolvents/Tetrahydrofuran/ ( last viewed Nov. 4, 2009).
Remington, The Science and Practice of Pharmacy, 20th edition, copyright 2000, chapter 16, pp. 218-220.
Deponte M et al:. “Mechanistic Studies on a Novel, Highly Potent Gold-Phosphole Inhibitor of Human Glutathione Reductase”, Journal of Biological Chemistry, American Society of Biolchemical Biologists, Birmingham, US vol. 280, No. 21, May 27, 2005, pp. 20628-20637, XP008059661, ISSN: 0021-9258 Le Document En Entier.
Hay C et al:, “A Bridging Ligand Featuring Terminal 2-Pyridylphosphole Moieties: Synthesis, Optical Poroperties and Ru(II)-Complex”, Journal of Organometallic Chemistry, Elsevier-Sequoia S.A. Lausanne, Ch, vol. 643-644, Feb. 1, 2002, pp. 494-497, XP004339612, ISSN: 0022-328X, Le Document En Entier.
Sautthier M et al:, “A Rare Phosphane Coordination Mode: A Symmetrically MU2-Bridging Phosphole in a Dinuclear Palladium(I) Complex”, Angewandte Chemie. International Edition, Verlag, Chemie. Weinheim, DE, vol. 40 No. 1, J Javier 2001 (Jan. 5, 2001), pp. 228-231, XP002223439, ISSN: 0570-0833, Le Document En Entier.
Leca, Francois et al:, “Stereospecific Isomerization of P-Heterocycles Triggered by Coordinationi Synthesis of the First P, N-Chelates Featuring A 2-Phospholene Moiety”, Chemical Communications (Cambridge, United Kingdom), (14), 1774-1775 Coden: CHCOFS; ISSN: 1359-7345, 2003, XP008044152, Le Document En Entier.
Sauthier M et al:, “Palladium Complexes of a Novel Family of P,N-Chelates, The 2-(2-Pyridyl) Phospholes: Synthesis, Structural Characterization and Catalytic Activity for Olefin/Co Copolymerization”, Organometallics, ACS, Washington, DC, US, vol. 21, No. 8, Apr. 15, 2002, pp. 1591-1602, XP001103869 ISSN: 0276-7333 Cite Dans la Demande le Document En Entier.

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