Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2005-05-10
2005-05-10
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
Reexamination Certificate
active
06890747
ABSTRACT:
The present invention relates PI3K crystals, polypeptide muteins, polypeptide fragments, antibodies thereto, nucleic acids coding for these polypeptides, methods of modifying PI3Kγ activity, and methods of modulating PI3Kγ activity. These include polypeptides and methods thereof, relating to, e.g., phospholipid binding, lipid kinase activity, modulating Ras activity in activating the PI3Kγ, binding of PI3Kγ to cell membranes, and modulating protein—protein interactions with PI3Kγ.
REFERENCES:
Stephens et al The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell. Apr. 4, 1997;89(1):105-14.
Ried Christian
Stephens Len
Walker Edward H.
Williams Roger
Giotta Gregory
Onyx Pharmaceuticals Inc.
Prouty Rebecca E.
Swope Sheridan L.
Warner-Lambert & Company
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