Phosphoglycolipid and methods for its use

Details Phosphoglycolipid and methods for its use Phosphoglycolipid and methods for its use

1998-08-21

2000-01-11

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 53, 536 55, 536 551, 53612313, A61K 31715, C08B 3700

Patent

active

060136405

ABSTRACT:
The invention concerns a novel phosphoglycolipid compound. The compound of the subject invention is 2-Deoxy-6-O-[2-deoxy-4-O-phosphono-3-O-[(R)-3-tetradecanoyloxytetradecanoy l]-2-[(R)-3-octadecanoyloxytetradecanoylamino]-.beta.-D-glucopyranosyl]-2-[ (R)-3-hexadecanoyloxytetradecanoylamino]-D-glucopyranose and pharmaceutically acceptable salts thereof. The compound is not immunoreactive, not pyrogenic, not toxic but is active in ameliorating tissue damage due to ischemia/reperfusion injury. Methods for using the subject compound to protect against reversible and irreversible damage due to ischemia/reperfusion injury are also disclosed.

REFERENCES:
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Brown et al. (Apr. 1989) Endotoxin pretreatment increases endo-genousmyocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Nat Acad Sci 86:2516-2520.
Elliott, G. Monophosphoryl Lipid A Induces Delayed Preconditioning Against Cardiac Ischemia-Reperfusion Injury. J Mol Cell Cardiol (Jan. 1998) 30:3-17.
Maulik et al. (1995) Myocardial adaptation to ischemia by oxidative stress induced by endotoxin. Am J. Physiol 269:C907-C916.
Mizumura et al. (Sep. 1995) Bimakalim, an ATP-sensitive potassium channel operner, mimics the effects of ischemic preconditioning to reduce infarct size, . . . Circulation 92:1236-1245.

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