Phosphoethanolamine conjugates of vitamin D compounds

Details Phosphoethanolamine conjugates of vitamin D compounds Phosphoethanolamine conjugates of vitamin D compounds

1996-08-27

1997-11-25

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, A61K 3159, C07C40100

Patent

active

056913281

ABSTRACT:
Certain phosphoethanolamine conjugates of vitamin D compounds are disclosed wherein the phosphoethanolamine moiety is bonded at the 3-position of the vitamin D moiety. The conjugates exhibit anti-tumor, anti-psoriatic and anti-inflammatory activities in addition to those activities associated with vitamin D. The invention embraces the novel compounds, pharmaceutical compositions thereof, and their methods of use.

REFERENCES:
patent: 5206229 (1993-04-01), Calverley et al.
patent: 5225579 (1993-07-01), Tahara
patent: 5342833 (1994-08-01), Doran et al.
Binderup, E.; Calverly, M.J., (1991) PCT Pat. Appl. No. WO91/00855.
Deluca, H.F.; Schnoes, H.K.; Perlman, K.L.; Kutner, A.; Brit. UK. Pat. Appl. GB 2,217,715 (01 Nov. 1989) U.S. Pat. Appl. 187,680 (29 Apr. 1988).
Deluca, H.F.; Schnoes, H.K.; Perlman, K.L., Brit. UK Pat. Appl. GB 2,217,716 (01 Nov. 1989, U.S. Pat. Appl. 187,615 (29 Apr. 1988)).
Schoenecker, B.; Reichenbaecher, M.; Giesling, S., Ger. Offen DE 4,334,154 (06 Apr. 1995).
Calverly, M.J., Tetrahedron (1987) 43(20):4609-4619.
Calverly, M.J., Trends Med. Chem. '90, Proc. Int. Symp. Med. Chem. 11th (1992), 299-306.
Kunkel, S.L., "Inflammatory Cytokines", pp. 1-15 in Manual of Vascular Mediators, P.A. Ward, Editor, produced by publishers of Hospital Practice.
Kutner, A. et al., (1986), Bioorganic Chemistry (1986) 14:134.
Murayama, E.; Muyamoto, H.; Kubodera, N.; Mori, T.; Matsunaga, I., Chem. Pharm. Bull. (1986) 34(10):4410-4413.
"Nomenclature of Vitamin D," Pure & Appl. Chem. (1982), 54(8):1511-1516.
Norman, A.W.; Schaefer, K.; Grigoluit, H.G.; Herrath, D.V. (Eds.) Proc. Workshop Vitam. D. 1988, 7th (Vitam. D) 1-78.
Norman, A.W.; Bouillon, R.; Thomasset, M., (Eds.) Proc. Workshop Vitam. D. 1991, 8th (Vitam. D) 127-217.
"Pharmacological Methods in the Control of Inflammation," Joseph Y. Chang and Alan J. Lewis (eds.) Alan R. Liss, Inc., New York, pp. 221-223.
Posner, G.; Dai, H.; Afarinkia, K.; Murthy, N.; Guyton, K.; Kensler, T., J. Org. Chem. (1993), 58:7209-7215.
Posner, G. and Johnson, N., J. Org. Chem. (1994), 59:7855-7861.
Ralph, W.C. and Nakoinz, I., "Antibody-Dependent Killing of Erythrocyte and Tumor Targets by Macrophage-Related Cell Lines: Enhancement by PPD and LPS.," J. Immunology (1977), 119:950-974.
Raschke, W.C.; Baird, S.; Ralph, P. and Nakoinz, I., "Functional Macrophage Cell Lines Transformed by Abelson Leukemia Virus," Cell (1978), 15:261-267.
Stamatov, S.D. and Gronowitz, S., Lipids (1990), 25(3):149-151.
Stork, G.; Hutchinson, D.; Okabe, M.; Parker, D.; Ra, C.; Ribereau, F.; Suzuki, T.; Zebovitz, T., Pure Appl. Chem. (1992), 64(12):1806-1812.
Taguchi, T.; Mitsuhashi, S.; Yamanouchi, A.; Kobayashi, Y.; Sai, H.; Ikekawa, N., Tetrahedron Lett. (1984), 25(43): 4933-4936.
M.A. Trush et al., "The Generation of Chemiluminescence by Phagocytic Cells," Methods in Enzymology (1978), 57:462-494.
Vitamin D Molecular, Cellular & Clinical Endocrinology, NY (1988).
Wolfgang, J., Synform (1985), 3(2):41-212.
Wolfgang, J., Synform (1986) 4(3):131-250.
Wolfgang, J., Synform (1987), 5(1):1-86.
S.H. Yuspa et al., Cancer Research (Dec. 1980), 40:4694-4703.
Stern, J., Internal Medicine, 4th edition, chapters 71-72, pp. 699-715, 1995.

Affiliated with

Also associated with

Rating

Phosphoethanolamine conjugates of vitamin D compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphoethanolamine conjugates of vitamin D compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphoethanolamine conjugates of vitamin D compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2107261