Phosphodiesterase enzymes

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07052895

ABSTRACT:
Amino acid sequences and nucleotide sequences relating to PDE1B2 are described. In a preferred aspect, the amino acid sequence comprises the sequence presented as SEQ ID No. 1.

REFERENCES:
patent: 5389527 (1995-02-01), Beavo et al.
patent: 5885834 (1999-03-01), Epstein
patent: 5932423 (1999-08-01), Au-Young et al.
patent: 5932465 (1999-08-01), Loughney
patent: 5955583 (1999-09-01), Loughney
Sequence alignment between Applicants' SEQ ID NO: 1 and Epstein's Accession No. AAW95110 (or SEQ ID No.:2).
Sequence alignment between Applicants' SEQ ID NO: 1 and Beavo et al. Accession No. AAR69720 (or SEQ ID No. 27).
Polli et al.,Proceedings of the Nathional Academy of Sciences of USA, vol. 89, No. 22, pp. 11079-11083 (1992).
Reed, Tracey M. et al.,Mammalian Genome,vol. 9, No. 7, pp. 571-576 (1998).
Yan. Chen et al.,Proceedings of the National Academy of Sciences of USA, vol. 92, No. 21, pp. 9677-9681 (1995).
Yu, Josephine et al.,Cell Signal, vol. 9, No. 7, pp. 519-529 (1997).

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