Phosphocholine derivative inhibitors of phospholipase A.sub.2

Details Phosphocholine derivative inhibitors of phospholipase A.sub.2 Phosphocholine derivative inhibitors of phospholipase A.sub.2

1992-06-03

1993-05-04

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 77, 514 78, 514109, 514114, 548119, 558169, A61K 3166, A61K 31675, C07F 902, C07F 928

Patent

active

052082237

ABSTRACT:
Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A.sub.2. Methods of making and using the compounds are also disclosed.

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Dennis, The Enzymes, Academic Press, vol., 16, Chapter 9 (1983).
Wilkenson, AntiInflammatory Phospholipase A.sub.2 Inhibitor Drugs to the Future, vol. 15, No. 2, p. 139-148 (1990).

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