Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-11-08
2008-03-18
Shiao, Rei-tsang (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S079000, C514S080000, C514S424000, C514S429000, C548S413000, C558S169000, C546S022000
Reexamination Certificate
active
07345082
ABSTRACT:
The present invention relates to phosphinic acid derivatives of formula Iwherein R1, R2, R3and R4are described hereinabove. These compounds can be used in the treatment or prevention of a disease related to the inhibition of β-secretase, inter alia for the treatment of Alzheimer's disease.
REFERENCES:
patent: 6630501 (2003-10-01), Dive et al.
patent: WO 03/040096 (2003-05-01), None
patent: WO 03/045913 (2003-06-01), None
patent: WO 03/072535 (2003-09-01), None
Lloyd et al., 1996, CAS: 125:196335.
Or Vincent et al., 1997, CAS: 127:117584.
Taylor W. G. et al., J. Agricultural & Food Chemistry, vol. 38 pp. 1422-1427 (1990).
Liu, X. et al., J. Organomet. Chem. vol. 646, pp. 212-222 (2002).
Sampson, N. S. et al., Biochemistry, vol. 30 pp. 2255-2263 (1991).
Baylis, E. K. et al., J. Chem. Soc. Perkin. Trans. vol. 1 pp. 2845-2853 (1984).
Dijols, S. et al., Biochemistry vol. 41, pp. 9286-9292 (2002).
Jacobs R. T. et al., J. Med. Chem. vol. 37, pp. 1282-1297 (1994).
Bailey, K. et al., Can. J. of Chem. vol. 49, pp. 3143-3151 (1971).
Vassiliou S. et al., Phosphinic pseudo-tripeptides as potent inhibitors of matrix metalloproteinases: a structure-activity study, Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 42, No. 14, pp. 2610-2620, (1999), XP002135494.
Yiotakis et al., Protection of the Hydroxyphosphinyl Function of Phosphinic Dipeptides by Adamantyl. Application to the Solid-Phase Synthesis of Phosphinic Peptides, Journal of Organic Chemistry, American Chemical Society, Easton, US, vol. 61, No. 1, pp. 6601-6605 (1996), XP002165430, p. 6605, col. 2, peptide 9.
Jiracek J. et al, Development of the First Potent and Selective Inhibitor of the Zincendopeptidase Neurolysin Using a Systematic Approach Based on Combinatorial Chemistry of Phosphinic Peptides, Journal of Biological Chemistry, vol. 271, No. 32, pp. 19606-19611 (1996), XP000677097.
Vincent Bruno et al, Effect of a Novel Selective and Potent Phosphinic Peptide Inhibitor of Endopeptidase 3.4.24.16 on Neurotensin-Induced Analgesia and Neuronal Inactivation, British Journal of Pharmacology, vol. 121, No. 4, pp. 705-710 (1997), XP002316977.
Yiotakis Athanasios et al, Cyclic Peptides with a Phosphinic Bond as Potent Inhibitors of a Zinc Bacterial Collagenase, Journal of Medicinal Chemistry, vol. 37, No. 17, pp. 2713-2720 (1994), XP002316978, p. 2717, col. 2, line 34-line 36.
Grobelny D et al, Selective Phosphinate Transition-State Analogue Inhibitors of the Protease of Human Immunodeficiency Virus, Biochemical and Biophysical Research Communications, vol. 169, No. 3, pp. 1111-1116 (1990), XP009043775.
Hilpert Hans
Humm Roland
Knopp Dietmar
Weiss Peter
Hoffmann-La Roche Inc.
Johnston George W.
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
Shiao Rei-tsang
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