Phosphinic acid derivatives with metallopeptidase inhibitory act

Details Phosphinic acid derivatives with metallopeptidase inhibitory act Phosphinic acid derivatives with metallopeptidase inhibitory act

1996-06-06

1998-02-10

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514119, 548117, 562 15, A61K 3166, A61K 3167, C07F 936

Patent

active

057169438

ABSTRACT:
Compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n have the meanings reported in the description are described.
The compounds of formula I are endowed with a dual ACE-inhibitory and NEP-inhibitory activity and are useful in the treatment of cardiovascular diseases.

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