Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1989-09-22
1991-04-09
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
540451, 540487, 544 93, 544 94, 544244, 546 24, 548112, 548413, 548414, 558170, 558174, C07F 932, C07F 9553, C07F 9572, C07F 9576
Patent
active
050066510
ABSTRACT:
The invention relates compounds of the formula ##STR1## wherein R.sup.1 -R.sup.5 and X have the significance given in the description, and their pharmaceutically acceptable salts. The compounds of formula I inhibit the enzyme collagenase and can be used in the form of medicaments for the control or prevention of degenerative joint diseases such as rheumatoid arthritis and osteoarthritis.
REFERENCES:
patent: 4226610 (1980-10-01), Takematsu et al.
Broadhurst Michael J.
Handa Balraj K.
Johnson William H.
Lawton Geoffrey
Machin Peter J.
Gould George M.
Hoffman-La Roche Inc.
Isgro William G.
Leon Bernard S.
Raymond Richard L.
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