Phosphine containing amino acids and peptides and methods of pre

Details Phosphine containing amino acids and peptides and methods of pre Phosphine containing amino acids and peptides and methods of pre

1994-03-30

1996-07-30

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

502159, 530345, 530334, 530336, 548412, 564 15, 585275, B01J 3124, C07F 950, C07K 1113, C07K 708

Patent

active

055412890

ABSTRACT:
A method for incorporating novel phosphine containing amino acids into peptide sequences is provided. The resulting phosphine-containing peptides can be used to bind a transition metal between two phosphine moieties presented on an amino acid in a peptide. The resulting phosphine-containing peptide metal complex is useful as a stereoselective catalyst of a chemical reaction or as a means for delivering a metal selectively to a target tissue or organ for medical uses.

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patent: 5061641 (1991-10-01), Shochat et al.
patent: 5112594 (1992-05-01), Woulfe et al.
patent: 5112595 (1992-05-01), Woulfe et al.
Grant, ed., Hackh's Chemical Dictionary, 4th ed., published 1969 by McGraw-Hill Book Co. (NY), p. 36.
Z. Naturforsch, vol. 38b, issued 1983, Trampisch et al, "Diphenylphosphino-2-aminosaureester als Liganden . . . ", pp. 365-369.
Recent Advances in Technetium Chemistry: Bridging Inorganic Chemistry and Nuclear Medicine, Comments Inorg. Chem. 3:83-103 (1984).
Lever, S., et al., Synthesis of a Novel Bifunctional Chelate Designed for Labeling Proteins with Technetium, Tetrahedron Letters 29:3219-3222 (1988) .

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