Phosphene oxide-terminated allene-ene-yne DNA-cleaving, antitumo

Details Phosphene oxide-terminated allene-ene-yne DNA-cleaving, antitumo Phosphene oxide-terminated allene-ene-yne DNA-cleaving, antitumo

1990-08-01

1993-07-20

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 82, 514 85, 514 86, 514 89, 514 90, 514 91, 514 94, 514 95, 514 96, 514 99, 514100, 544232, 544243, 544244, 544337, 546 22, 546 23, 546 24, 548112, 548113, 548119, 548413, 548414, 548415, 549 5, 549 6, 549218, 549220, 560 21, 560 51, 560 59, 560 60, 560 61, 560 64, 560 65, 560 66, 560 81, 568 15, C07D21104, C07D21502, C07D22102, C07C 69007, A61K 31045, A61K 3121, A61K 3133, C07F 953

Patent

active

052293750

ABSTRACT:
Phosphine oxide-terminated allene-ene-yne compounds are disclosed that possess DNA-cleaving, antimicobial and tumor growth-inhibiting properties. Methods of making and using those compounds are also disclosed.

REFERENCES:
patent: 4079125 (1978-03-01), Sipos
Nicolaou et al., J. Am. Chem. Soc., 110:7247 (1988); "DNA Cleavage by a Synthetic Mimic of the Calicheamicin-Esperamicin Class of Antibiotics".
Nicolaou et al., Agnew. Chem. Int. Ed. Engl., 28:1272 (1989).
Povsic et al., J. Am. Chem. Soc., 111:3059 (1989).
Hertzberg et al., J. Am. Chem. Soc., 104:313 (1982).
Moser et al., Science, 238:645 (1987).
Corey et al., J. Am. Chem. Soc., 111:8523 (1989).
Pyle et al., J. Am. Chem. Soc., 111:4520 (1989).
Thederahn et al., J. Am. Chem. Soc., 111:4941 (1989).
Otsuka et al., J. Am. Chem. Soc., 112:838-845 (1990).
Mantlo et al. J. Org. Chem., 54:2781 (1989).
Nagata et al., Tetrahedron Lett., 30:4995 (1989).
Lee et al., J. Am. Chem. Soc., 109:3464 (1987).
Hawley et al.,. Proc. Natl. Acad. Sci., USA, 86:1105 (1989).
Golik et al., J. Am. Chem. Soc., 109:3461 (1987).
Edo et al., Tetrahedron Lett., 26:331 (1984).
Chin et al., Biochemistry, 27:8106 (1988).
Lee et al., Biochemistry, 28:1019 (1989).
Meyers et al., J. Am. Chem. Soc., 111:8057 (1989).
Meyers et al., J. Am. Chem. Soc., 111:9130 (1990).
Kappen et al., J. Am. Chem. Soc., 112:2797 (1990).
Zein et al., Science, 240:1198 (1988).
Haseltine et al., J. Am. Chem. Soc., 111:7638 (1989).
Golik et al., J. Am. Chem. Soc., 109:3462 (1987).

Affiliated with

Also associated with

Rating

Phosphene oxide-terminated allene-ene-yne DNA-cleaving, antitumo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphene oxide-terminated allene-ene-yne DNA-cleaving, antitumo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphene oxide-terminated allene-ene-yne DNA-cleaving, antitumo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1760554