Phosphazene polymer for immobilizing biologically active substan

Details Phosphazene polymer for immobilizing biologically active substan Phosphazene polymer for immobilizing biologically active substan

1990-10-26

1993-12-07

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435180, 435803, 435815, 436531, 436532, 528399, 530413, 530815, 530816, C12N 1106, G01N 33549, C08G 7902, C07K 1700

Patent

active

052682870

ABSTRACT:
A phosphazene polymer for immobilizing biologically active substances such as enzymes is prepared that does not lower activity originally possessed by the biologically active substance and does not contain a functionality which can adsorb undesired substances. The polymer has organic radicals having a functional group capable of binding a biologically active substance and organic radicals which are non-reactive and hydrophilic. The non-reactive and hydrophilic organic radicals are preferably prepared by reacting a side chain of the polymer having a primary amino group with formaldehyde or by diazotizing the primary amino group followed by hydrolysis to form a hydroxyl group. A biologically active substance immobilized on the polymer can be used to separate a substance that has affinity for the immobilized biologically active substance.

REFERENCES:
patent: 3666733 (1972-05-01), Epton
patent: 3669841 (1972-06-01), Miller
patent: 4451619 (1984-05-01), Heilmann et al.
Guiseppi-Elie, et al., Journal of Polymer Science, vol. 23, 1985, pp. 2601-2613.
Allcock et al., Macromolecules, vol. 16, No. 9, 1402-1406, 1983.
World Patents Index Latest, Derwent Publications, Ltd., London, GB; AN 85-163620 & SU-A-1 085 993 (Moscow Mendeleev) Apr. 15, 1984.
Macromolecules, vol. 19, No. 6, Jun. 119, 1986, pp. 1502-1508; H. R. Allcock: "Covalent Linkage of Proteins".

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