Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1987-10-06
1991-03-05
Warren, Charles F.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352351, 424450, 514 78, 436829, C12N 500, A61K 3100, A61K 3700
Patent
active
049977610
ABSTRACT:
Phosphatides are shown to have antiviral activity, where the phosphatides are characterized by having a polyunsaturated fatty acid at the sn2 position. By contacting cells susceptible to or infected with a virus, particularly a retrovirus, the proliferation of the virus is substantially inhibited.
REFERENCES:
patent: 4666893 (1987-05-01), Tsuichya
"A Special Lipid Mixture for Membrane Fluidization", by Lyte et al. in Biochimica et Biophysica Acta (1985), 812:133-138.
"Effects of a Novel Compound (AL721) on HTLV-III Infectivity in Vitro", by Sarin et al., in New England Journal of Medicine, (1985) 313: No. 20.
"AL721, A Novel Membrane Fluidizer", by Antonian et al. in Neuroscience and Biobehavioral Reviews (1987) 11:399-413.
Schlegel et al., Cell 32:639-646, 1983, "Inhibition of VSV Binding and Infectivity by Phosphatidy/Serine: Is Phosphatidy/Serine a VSV-Binding Site?".
Jett et al., B B Res Comm 114: 863-871, 1983, "Selective Cytotoxicity of tumor Cells Induced by Liposomes Containing Plant Phosphatidylinositol".
Norley et al. J. Immun./36: 681-685, 1986, "Targeting of Drug Loaded Immunoliposomes to HSV Infected Corneal Cells: An Effective Means of Inhibiting Virus Replication In Vitro".
Chambers Jasemine C.
Houston Biotechnology Incorporated
Rae-Venter Barbara
Rowland Bertram I.
Warren Charles F.
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