Phosphate transport inhibitors

Details Phosphate transport inhibitors Phosphate transport inhibitors

2006-10-10

2006-10-10

Wang, Shengjun (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C514S613000, C514S617000

Reexamination Certificate

active

07119120

ABSTRACT:
Disclosed are compounds which have been identified as inhibitors of phosphate transport. Many of the compounds are represented by Structural Formula (I):in-line-formulae description="In-line Formulae" end="lead"?Ar1—W—X—Y—Ar2;in-line-formulae description="In-line Formulae" end="tail"?or a pharmaceutically acceptable salt thereof. Ar1and Ar2are independently a substituted or unsubstituted aryl group or an optionally substituted five membered or six membered non-aromatic heterocylic group fused to an optionally substituted monocylic aryl group. W and Y are independently a covalent bond or a C1–C3 substituted or unsubstituted alkylene group. X is a heteroatom-containing functional group, an aromatic heterocyclic group, substituted aromatic heterocyclic group, non-aromatic heterocyclic group, substituted non-aromatic heterocyclic group, an olefin group or a substituted olefin group. Also disclosed are methods of treating a subject with a disease associated with hyperphosphatemia, as well as a disease mediated by phosphate-transport function. The methods comprise the step of administering an effective amount of the one of the compounds described above.

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