Phosphate transport inhibitors

Details Phosphate transport inhibitors Phosphate transport inhibitors

2006-09-19

2006-09-19

Richter, Johann (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

C514S102000, C546S022000, C558S155000, C558S156000, C558S158000, C558S159000, C562S013000, C562S021000

Reexamination Certificate

active

07109184

ABSTRACT:
Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I):R1 and R2 are independently —H, an electron withdrawing group or a C1–C10alkyl group.Y is a covalent bond, a substituted methylene group, an unsubstituted methylene group or —CR1R2P(O)(OH)—.R3 is a hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a substituted hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a heteroaryl group, a substituted heteroaryl group or a phenyl group substituted with one or more groups selected from —Cl, —Br, —F, —CN, —NO2, —ORa, —N(Ra)2, —COORa, —CON(Ra)2, —CORa, —S(O)Ra, —S(O)2Ra, —S(O)2N(Ra)2, —NRaS(O)2Ra, —NRaCORa, a halogenated lower alkyl group, an aryl group, a substituted aryl group, or a halogenated alkoxy group.Each Rais independently —H, lower alkyl, substituted lower alkyl, aryl or substituted aryl.Each Rb is independently —H, a lower alkyl group, or a phosphate protecting group.

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