Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1999-04-01
2000-04-04
Rotman, Alan L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544253, 544349, 546112, C07D23726, C07D23970, C07D24136, C07F 980
Patent
active
060463279
ABSTRACT:
This invention relates to a cyclization process useful in the preparation of a key intermediate in the preparation of an endothelin antagonist of the general formula shown below: ##STR1##
REFERENCES:
patent: 5389620 (1995-02-01), Ishikawa et al.
patent: 5849914 (1998-12-01), Dolling et al.
Taylor, et al., Tetrahedron Letters, vol. 27(19), pp. 2107-2110, 1986.
Taylor, et al., J. Org. Chem., vol. 56(5), pp. 1807-1812, 1991.
Song Zhiguo
Tillyer Richard D.
Tschaen David M.
Zhao Mangzu
Camara Valerie J.
Daniel Mark R.
Desai Rita
Merck & Co. , Inc.
Rotman Alan L.
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