Phosphate-bearing prodrugs of sulfonyl hydrazines as...

Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfinate esters

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C562S008000, C558S154000, C558S193000, C558S190000

Reexamination Certificate

active

11232252

ABSTRACT:
Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Pharmaceutical compositions and uses thereof in the treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy.where R is C1-C10alkyl or haloalkyl;R′ and R″ are each independently C1-C10alkyl;R1is CH3; andX is O;or a pharmaceutically acceptable salt, solvate, polymorph or metabolite thereof.

REFERENCES:
patent: 4684747 (1987-08-01), Sartorelli et al.
patent: 4849563 (1989-07-01), Sartorelli et al.
patent: 5101072 (1992-03-01), Sartorelli et al.
patent: 5214068 (1993-05-01), Sartorelli et al.
patent: 5256820 (1993-10-01), Sartorelli et al.
patent: 5637619 (1997-06-01), Sartorelli et al.
patent: 5767134 (1998-06-01), Li et al.
patent: 6040338 (2000-03-01), Sartorelli et al.
patent: 6458816 (2002-10-01), Doyle et al.
patent: 6855695 (2005-02-01), Lin et al.
Hockel et al., Cancer Res. 1991, 51:6098.
Brizel et al., Radiother Oncol. 1999, 53:113.
Stratford et al, Anticancer Drug Des. 1998, 13:519.
Ashur-Fabian et al., Proc. Natl. Acad. Sci. USA 2004. 101:12236.
Yang et al., Cancer Res. 2003, 63:1520.
Korbelik et al., Mutal. Res. 1980, 78:201.
Shealy et al., J. Med. Chem. 1984, 27:664.
Shyam et al., J.Med. Chem. 1999, 42:941.
Seow et al., Proc. Natl. Acad. Sci. USA 2005, 102:9282.
Shyam et al., J. Med. Chem. 1993, 36:3496.
Shyam et al., J. Med. Chem. 1996, 39:796.
Majer et al., J. Org. Chem. 1994, 59:1937.
Pridgen et al., J. Org. Chem. 1989, 54:3231.
Matulic-Adamic et al., J. Org. Chem. 1995, 60:2563.
Durgam et al., J. Med. Chem. 2005, 48:4919.
Jansson et al., Tetrahedron Lett. 1986, 27:753.
Mathre et al., J. Org. Chem. 1993, 58:2880.
Brown et al., J. Am. Chem. Soc. 1988, 110:1539.
Ramachadran et al., Tetrahedron: Asymm. 5: 1061.
Ohkuma et al., J. Am. Chem. Soc. 1998, 120:13529.
Baar et al., J. Am. Chem. Soc. 2004, 126:8216.
Silverberg et al., Tetrahedron Lett. 1996, 37:771.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Phosphate-bearing prodrugs of sulfonyl hydrazines as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphate-bearing prodrugs of sulfonyl hydrazines as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphate-bearing prodrugs of sulfonyl hydrazines as... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3934484

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.