Phosphate-bearing prodrugs of sulfonyl hydrazines as...

Details Phosphate-bearing prodrugs of sulfonyl hydrazines as... Phosphate-bearing prodrugs of sulfonyl hydrazines as...

2008-07-29

2008-07-29

Anderson, Rebecca (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfinate esters

C562S008000, C558S154000, C558S193000, C558S190000

Reexamination Certificate

active

07405317

ABSTRACT:
Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Pharmaceutical compositions and uses thereof in the treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy.where R is C1-C10alkyl or haloalkyl;R′ and R″ are each independently C1-C10alkyl;R1is CH3; andX is O;or a pharmaceutically acceptable salt, solvate, polymorph or metabolite thereof.

REFERENCES:
patent: 4684747 (1987-08-01), Sartorelli et al.
patent: 4849563 (1989-07-01), Sartorelli et al.
patent: 5101072 (1992-03-01), Sartorelli et al.
patent: 5214068 (1993-05-01), Sartorelli et al.
patent: 5256820 (1993-10-01), Sartorelli et al.
patent: 5637619 (1997-06-01), Sartorelli et al.
patent: 5767134 (1998-06-01), Li et al.
patent: 6040338 (2000-03-01), Sartorelli et al.
patent: 6458816 (2002-10-01), Doyle et al.
patent: 6855695 (2005-02-01), Lin et al.
Hockel et al., Cancer Res. 1991, 51:6098.
Brizel et al., Radiother Oncol. 1999, 53:113.
Stratford et al, Anticancer Drug Des. 1998, 13:519.
Ashur-Fabian et al., Proc. Natl. Acad. Sci. USA 2004. 101:12236.
Yang et al., Cancer Res. 2003, 63:1520.
Korbelik et al., Mutal. Res. 1980, 78:201.
Shealy et al., J. Med. Chem. 1984, 27:664.
Shyam et al., J.Med. Chem. 1999, 42:941.
Seow et al., Proc. Natl. Acad. Sci. USA 2005, 102:9282.
Shyam et al., J. Med. Chem. 1993, 36:3496.
Shyam et al., J. Med. Chem. 1996, 39:796.
Majer et al., J. Org. Chem. 1994, 59:1937.
Pridgen et al., J. Org. Chem. 1989, 54:3231.
Matulic-Adamic et al., J. Org. Chem. 1995, 60:2563.
Durgam et al., J. Med. Chem. 2005, 48:4919.
Jansson et al., Tetrahedron Lett. 1986, 27:753.
Mathre et al., J. Org. Chem. 1993, 58:2880.
Brown et al., J. Am. Chem. Soc. 1988, 110:1539.
Ramachadran et al., Tetrahedron: Asymm. 5: 1061.
Ohkuma et al., J. Am. Chem. Soc. 1998, 120:13529.
Baar et al., J. Am. Chem. Soc. 2004, 126:8216.
Silverberg et al., Tetrahedron Lett. 1996, 37:771.

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