Phosphatase inhibitors and methods of use thereof

Details Phosphatase inhibitors and methods of use thereof Phosphatase inhibitors and methods of use thereof

1996-07-30

1997-12-23

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514313, 514314, 514326, 514340, 514255, 544369, 546167, 546169, 546171, 546209, 5462714, A61K 3142, C07D26332

Patent

active

057008213

ABSTRACT:
The present invention is directed to compounds having the formula: ##STR1## The invention further provides a method of making the compounds. The compounds are useful as inhibitors of protein phosphatases, for example PP1, PP2A, PP3, CDC25A and CDC25B. The invention is further directed to a method of inhibiting a protein phosphatase, a method of inhibiting cell proliferation, and pharmaceutical compositions comprising the subject compounds.

REFERENCES:
patent: 5280034 (1994-01-01), Hall et al.
Honkanan et al. (1994) Toxicon 32: 339.
MacKintosh et al. (1995) FEBS Letters 371: 236.
Murray et al. (1994) Annual Reports in Medicinal Chemistry 29: 255.
Nishiwaki et al. (1990) Carcinogenesis 11: 1837.
Quinn et al. (1993) Bioorganic and Medicinal Chemistry Letters 3: 1029.
Sugiyama et al. (1995) Bioorganic and Medicinal Chemistry Letters 6: 3.
Takai et al. (1992) Biochem. J. 284: 539.
Taylor et al. (1992) Bioorganic and Medicinal Chemistry Letters 2: 299.
Thompson et al. (1996) Chem. Rev. 96: 555.

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