Phosphatase inhibitors and methods of use thereof

Details Phosphatase inhibitors and methods of use thereof Phosphatase inhibitors and methods of use thereof

1997-08-22

1999-07-20

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514313, 514314, 514326, 514340, 514255, A61K 3142, A61K 3147, A61K 31445, A61K 3144, A61K 31495

Patent

active

059256605

ABSTRACT:
The present invention is directed to compounds having the formula: ##STR1## The invention further provides a method of making the compounds. The compounds are useful as inhibitors of protein phosphatases, for example PP1, PP2A, PP3, CDC25A and CDC25B. The invention is further directed to a method of inhibiting a protein phosphatase, a method of inhibiting cell proliferation, and pharmaceutical compositions comprising the subject compounds.

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