Phosphatase inhibitors and methods of use thereof

Details Phosphatase inhibitors and methods of use thereof Phosphatase inhibitors and methods of use thereof

1997-08-22

1999-01-05

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544369, 5483001, 548369, 546167, 546169, 546171, C07D26332

Patent

active

058565060

ABSTRACT:
The present invention is directed to compounds having the formula: ##STR1## The invention further provides a method of making the compounds. The compounds are useful as inhibitors of protein phosphatases, for example PP1, PP2A, PP3, CDC25A and CDC25B. The invention is further directed to a method of inhibiting a protein phosphatase, a method of inhibiting cell proliferation, and pharmaceutical compositions comprising the subject compounds.

REFERENCES:
patent: 5280034 (1994-01-01), Hall et al.
patent: 5583232 (1996-12-01), Kempf et al.
Honkanan et al. (1994) Toxicon 32: 339.
macKintosh et al. (1995) FEBS Letters 371: 236.
Murray et al. (1994) Annual Reports in Medicinal Chemistry 29: 255.
Nishiwaki et al. (1990) Carcinogenesis 11 : 1837.
Quinn et al. (1993) Bioorganic and Medicinal Chemistry Letter3 : 1029.
Sugiyama et al (1995)Bioorganic and Medicinal Chemistry Letters 6: 3.
Takai et al. (1992) Biochem. J. 284 : 539.
Taylor et al. (1992) Bioorganic and Medicinal Chemistry Letters 2 : 299.
Thompson et al. (1996) Chem. Rev. 96: 555.

Affiliated with

Also associated with

Rating

Phosphatase inhibitors and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphatase inhibitors and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphatase inhibitors and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-863824