Phosphatase inhibitors and methods of use thereof

Details Phosphatase inhibitors and methods of use thereof Phosphatase inhibitors and methods of use thereof

1997-08-22

2000-03-21

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3142

Patent

active

060403233

ABSTRACT:
The present invention is directed to compounds having the formula: ##STR1## The invention further provides a method of making the compounds. The compounds are useful as inhibitors of protein phosphatases, for example PP1, PP2A, PP3, CDC25A and CDC25B. The invention is further directed to a method of inhibiting a protein phosphatase, a method of inhibiting cell proliferation, and pharmaceutical compositions comprising the subject compounds.

REFERENCES:
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patent: 5583232 (1996-12-01), Kempf et al.
Honkanan et al. (1994) Toxicon 32:339.
MacKintosh et al. (1995) FEBS Letters 371:236.
Murray et al. (1994) Annual Reports in Medicinal Chemistry 29:255.
Nishiwaki et al. (1990) Carcinogenesis 11:1837.
Quinn et al. (1993) Bioorganic and Medicinal Chemistry Letters 3:1029.
Sugiyama et al (1995) Bioiorganic and Medicinal Chemistry Letters 6:3.
Takai et al. (1992) Biochem. J. 284:539.
Taylor et al. (1992) Bioorganic and Medicinal Chemistry Letters 2:299.
Thompson et al. (1996) Chem. Rev. 96:555.

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