Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Patent
2000-02-03
2000-12-12
Ceperley, Mary E.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
558161, 558165, C07F 9165
Patent
active
061601535
ABSTRACT:
The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.--2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided.
Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality.
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Bieniarz Christopher
Cornwell Michael J.
Skrzypczynski Zbigniew
Young Douglas F.
Abbott Laboratories
Anderson Regina M.
Ceperley Mary E.
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