Phosphatase activated crosslinking, conjugating and reducing age

Details Phosphatase activated crosslinking, conjugating and reducing age Phosphatase activated crosslinking, conjugating and reducing age

1996-05-29

2000-05-02

Ceperley, Mary E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

526278, 536 171, 548413, 558159, 558162, C07K 1700, C07F 916

Patent

active

060574291

ABSTRACT:
The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.-2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided.
Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality.

REFERENCES:
patent: 4843126 (1989-06-01), Quinn
patent: 5232484 (1993-08-01), Pignatello
patent: 5376403 (1994-12-01), Capote et al.
patent: 5674514 (1997-10-01), Hasslin
B. Connolly et al., J. Biol. Chem., vol. 257(7), pp. 3382-3384, Apr. 1982.

Affiliated with

Also associated with

Rating

Phosphatase activated crosslinking, conjugating and reducing age does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphatase activated crosslinking, conjugating and reducing age, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphatase activated crosslinking, conjugating and reducing age will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1594853