Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1994-01-27
1997-04-29
Fleisher, Mindy
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530350, 530413, 530839, 424570, C07K 1447, C07K 14435, C07K 122, A61K 3530
Patent
active
056250401
ABSTRACT:
A phosphacan proteoglycan molecule, or a functional derivatives thereof, binds to brain cells and to a number of cell adhesion molecules including Ng-CAM and N-CAM. Such proteoglycan molecules or functional derivatives, as well as nucleic acids coding therefore are useful in treating a subject having a disorder associated with conditions where it is desirable to promote nerve regeneration. The compositions and methods of the present invention are also useful for diagnosing and monitoring human tumors such as gliomas and astrocytomas.
REFERENCES:
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Oohira et al. "Inhibitory Effects of Brain Chondroitin Sulfate Proteoglycans on Neurite Outgrowth form PC 12D Cells" J. Neurosci. 11(3) 822-827 1991.
Margolis et al. "Nervous Tissue Proteoglycans" Experientia 49 429-446 1993.
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Krusius, T. et al., "Structural Studies on Sialylated and Sulphated O-Glycosidic Mannose-linked Oligosaccharides in the Chondroitin Sulphate Proteoglycan of Brain" (1987) Biochem. J. 245:229-234.
Grumet, M., "Structure, Expression, and Function of Ng-CAM, a Member of the Immunoglobulin Superfamily Involved in Neuron-Neuron and Neuron-Glia Adhesion" (1992) J. Neurosci. Res. 31:1-13.
Reid, R.A. et al., "Variants of Human L1 Cell Adhesion Molecule Arise Through Alternate Splicing of RNA" (1992) J. Mol. Neurosci. 3:127-135.
Krueger et al., "A Human Transmembrane Protein-Tyrosine-Phosphatase, PTPepsilon, Is Expressed in Brain and Has a N-Terminal Receptor Domain Homologous to Carbonic Anhydrases", Proc. Natl. Acad. Sci. 89:7417-7421 (1992).
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Margolis Renee K.
Margolis Richard U.
Maurel Patrice
Degen Nancy J.
Fleisher Mindy
New York University
The Research Foundation of State University of New York
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