Phosophoinositoglycan binding proteins

Details Phosophoinositoglycan binding proteins Phosophoinositoglycan binding proteins

2006-03-16

2008-11-11

Saidha, Tekchand (Department: 1652)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

C530S412000, C435S007100

Reexamination Certificate

active

07449560

ABSTRACT:
The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin signaling cascade.

REFERENCES:
patent: 0532915 (1997-01-01), None
Weid et al., Convergence and divergence of the signaling pathways for insulin and phosphoinositolglycans.Mol Med. May 1998;4(5):299-323.
Frick et al., Insulin-mimetic signalling of synthetic phosphoinositolglycans in isolated rat adipocytes.Biochem J. Nov. 15, 1998;336 ( Pt 1):163-181.
Muller et al., Phosphoinositolglycan-peptides from yeast potently induce metabolic insulin actions in isolated rat adipocytes, cardiomyocytes, and diaphragms. Endocrinology. Aug. 1997;138(8):3459-3475.
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Gunter Muller et al., Convergence and Divergence of the Signaling Pathways for Insulin and Phophoinositolglycans, Molecular Medicine, 1998, pp. 299-323, vol. 4.
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Gunter Muller et al., Phosphoinositolglycan-Peptides from Yeast Induce Metabolic Insulin Actions in Isolated Rat Adipocytes, Cardiomyocytes and Diaphragms, Endocrinology, 1997, pp. 3459-3475, vol. 138, No. 8.
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Gunter Muller et al., Signaling via caveolin: involvement in the cross-talk betweeen phosphoinositolglycans and insulin, CMLS, Cell. Mol. Life Sci., 1999, p. 945-970, vol. 56.
Gunter Muller et al., Cross Talk of pp125 FAK and P59Lyn Non-Receptor Tyrosine Kinase to Insulin-Mimetic Signaling in Adipocytes, Molecular and Cellular Biology, 2000, pp. 4708-4723, vol. 20, No. 13.
Gunter Muller et al, Cholesterol Depletion Blocks Redistribution of Lipid Raft Components and Insulin-Mimetic Signaling by Glimepiride and Phosphoinositolglycans in Rat Adipocytes, Molecular Medicine, vol. 8, No. 3, Mar. 2002, pp. 120-136.
Morris et al., Sortilin Is the Major 110-kDa Protein in GLUT4 Vesicles from Adipocytes, Journ of Biological Chemistry, vol. 273, No. 6, Feb. 6, 1998, pp. 3582-3587.
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