Surgery – Diagnostic testing – Respiratory
Utility Patent
1996-10-04
2001-01-02
Nasser, Robert L. (Department: 3736)
Surgery
Diagnostic testing
Respiratory
C600S538000, C600S586000
Utility Patent
active
06168568
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a method, system and apparatus for the detection and analysis of body sounds in general and to a method, system and apparatus for the automatic detection and analysis of breath sounds in particular.
BACKGROUND OF THE INVENTION
The art of listening to body sounds, or auscultation, has been used by physicians for thousands of years, for diagnosing various diseases.
Auscultation was initially performed by placing the physician's ear directly on the skin of the patient. At the beginning of the 19th century, R. T. La{umlaut over (e)}nnec introduced a tool, the stethoscope, for transmitting of body sounds to the ear.
Currently used stethoscopes include a “chest piece” brought into contact with the patient's skin, and two flexible tubes, terminating in the physician's ears. Pulmonary sounds are typically classified into normal breath sounds and adventitious (abnormal) breath sounds. The type of adventitious breath sounds, their temporal location relative to the inspiration and expiration phases of the respiratory cycle and their rate of occurrence are used to diagnose the nature and severity of pulmonary diseases.
Adventitious breath sounds are usually divided into continuous and discontinuous sounds depending on their duration. Continuous sounds are further subdivided into wheezes, which are higher pitched musical sounds indicating the presence of airway narrowing and rhonchi, which are low-pitched, grinding sounds. Discontinuous adventitious breath sounds are similarly divided into coarse crackles, which are short intermittent explosive sounds having a lower pitch, and fine crackles, which are less loud, shorter in duration, and higher in pitch. Crackles are usually indicative of obstructive airway diseases or restrictive lung diseases (depending on their timing in the respiratory cycle).
The use of various sensors which transform the acoustic signals of the body into electrical voltages is well known in the art. Various types of transducers have been used in implementing body sound sensors, including both air coupled and contact microphones or accelerometers. An improved contact sensor for body sounds has been disclosed by the present inventor in U.S. patent application Ser. No. 08/654,643 filed on May 29, 1996 and entitled “A Contact Sensor for Body Sounds”.
The introduction of computerized signal processing methods has facilitated quantitative and objective analysis of breath sounds. Methods have been developed which transform the acoustic signals to the frequency domain, characterize the signals' temporal and spectral patterns, and extract features that distinguish the various classes of normal and abnormal breath sounds, as described in the book,
Breath Sounds Methodology
by Noam Gavriely, CRC Press Inc, 1995.
U.S. Pat. No. 5,213,108 to Bredesen and Schmerler discloses a visual display stethoscope which enables the visual display of acoustic data including breath sounds and manual measurement of certain parameters of the acoustic waveform. Methods involving the manual analysis of visually displayed digitized waveforms are time consuming, require the analysis to be performed by an expert and lack objective and uniform criteria for quantitative identification of adventitious sounds.
Published PCT Application WO 91/03981 to Murphy discloses a system and method for automatically detecting and identifying certain adventitious sounds. The method of crackle identification is based on two primary parameters, the amplitude and duration of the crackle wave (half cycle), and on one secondary parameter, the slope of one of the waves.
Crackle detection methods based on wave amplitude analysis as a primary detection criterion have an inherent disadvantage due to the fact that the amplitude of crackles is often similar to or even smaller than the amplitude of the underlying breath sounds. A simple threshold crossing criterion will miss the majority of crackles, thus rendering the rest of the analysis useless.
Nocturnal respiratory symptoms are common, yet difficult to assess. They include nighttime dyspnoea caused by cardiac, gastrointestinal, and pulmonary disease processes. Paroxysmal nocturnal dyspnoea (PND) is a symptom of congestive heart failure (CHF) where water accumulates in the lung of the supine patient and interferes with alveolar gas exchange. This process leads to a sudden onset of breathlessness, usually during the third part of the night, which is relieved by shifting to an upright posture. Gastro-esophageal reflux of acidic content from the stomach in supine patients is often associated with aspiration of the acid into the airways that causes an acute onset of cough, wheezing and dyspnoea. A nighttime onset of asthma attacks is common in children. It is often suspected by the physician after hearing a description of the course of events by a parent, but an objective diagnosis is difficult. Especially since at least some of these children have normal physical examination and spirometry during the day. Another class of nocturnal breathing disorders is the obstructive sleep-apnea (OSA) syndrome and its related conditions (hypopnea, snoring). In these conditions, the patient's upper airway collapses or becomes narrowed or flutter develops, leading to a complete or partial interruption of the flow. OSA causes interference with the normal pattern of sleep, multiple (some time as many as hundreds) arousals during the night and reduced oxygenation.
Each of these clinical conditions have distinct breath sound features. Progressive pulmonary water overload is initially associated with the generation of inspiratory crackles, with an increasing range of chest wall distribution, and eventually, the emerging of expiratory crackles and wheezes. In addition, there is a gradual increase in the respiratory rate (tachypnea). An acute onset of cough, wheezing and secretion sounds (rhonchi and expiratory crackles) is a marker of aspiration. Finally, a gradual onset of wheezing with or without coughing is associated with bronchial asthma.
A disadvantage of the prior art of manual auscultation is that it cannot provide a reliable objective and continuous detection and documentation of the occurrence of nocturnal adventitious breath sounds with respect to time, and while the patient is sleeping. Thus, prior art auscultation methods do not provide a reliable objective method for accurately diagnosing and documenting respiratory symptoms.
SUMMARY OF THE PRESENT INVENTION
There is therefore provided, in accordance with a preferred embodiment of the present invention, a phonopneumograph system for analyzing breath sounds, the phonopneumograph system includes a plurality of breath related sensors placed around the respiratory system of a patient for measuring breath related activity, a breath analyzer for matching the breath sound data produced by the breath related sensors to a plurality of breath sound templates each of which parametrize one type of breath sound and for determining the presence of regular and/or adventitious breath sounds only when the breath sound data matches, within predetermined goodness of fit criteria, one or more of the breath sound templates.
Additionally, in accordance with a preferred embodiment of the present invention, the sensors include at least one of the following type of sensors: chest expansion sensors, breath sounds sensors, tracheal sound sensors, flow meters and spirometers.
Moreover, in accordance with a preferred embodiment of the present invention, the plurality of breath sound templates parametrize at least one of the following sounds: regular chest wall breath sound, regular tracheal breath sound, a wheeze, a cough, a rhonchus, a snore and a crackle.
Additionally, in accordance with a preferred embodiment of the present invention, the phonopneumograph system also includes an ambient noise microphone for measuring ambient noise data from the space in which a patient is.
Further, in accordance with a preferred embodiment of the present invention, the template for regular chest w
Fenster & Company Patent Attorneys Ltd.
Karmel Medical Acoustic Technologies Ltd.
Nasser Robert L.
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