Phloretin and phlorizin derivative containing compounds

Details Phloretin and phlorizin derivative containing compounds Phloretin and phlorizin derivative containing compounds

1984-09-06

1988-07-26

Brown, J. R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 172, 536 51, 536 52, 536 56, 536112, 536114, C07H 1504

Patent

active

047601353

ABSTRACT:
Compounds including phloretin and/or phlorizin derivatives coupled to an undigestible and non-absorbable matrix are provided. The compounds have pharmacological efficacies. They inhibit sugar uptake from the intestine and may be used in composition form in methods for treating diabetes and for promoting weight loss. A method for the manufacture of these compounds and a novel intermediate phlorizin derivative for making these compounds are also disclosed.

REFERENCES:
patent: 3523937 (1970-08-01), Biegeleisen
patent: 4224439 (1980-09-01), Ayers et al.
Takeshi Kasagi, "Inhibition of Glucose Transport in the Rat's Small Intestine by Cellulose-Phlorizin", 1981, p. 250.
Diedrich, "The Comparative Effects of Some Phlorizin Analogs on the Renal Reabsorption of Glucose", 1962, pp. 688-700.
Diedrich, "In Vitro Evaluation of Relative Inhibitory Potency of Phlorizin and Its Congeners", 1965, pp. 621-626.
Diedrich, "Competitive Inhibition of Intestinal Glucose Transport by Phlorizin Analogs", 1966, pp. 248-246.
Bode, Baumann & Diedrich, "Inhibition of [.sup.3 H] Phlorizin Binding to Isolated Kidney Brush Border Membranes . . . ", 1972, pp. 134-149.
Vick, Diedrich & Baumann, "Re-evaluation of Renal Tubular Glucose Transport Inhibition by Phlorizin Analogs", 1973, pp. 552-557.
Warden, (Dissertation), "Intestinal Absorption of Glucose Hydrolyzed . . . Membranes", 1982, pp. 188+.

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