Phep, an amino acid permease of Staphylococcus aureus

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

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C424S234100, C424S185100, C424S190100, C530S300000, C530S350000

Reexamination Certificate

active

07740869

ABSTRACT:
The present invention relates to antigenic polypeptides expressed by pathogenic microbes, including antigenic polypeptides encoded by the nucleic acid sequence of FIG.1, vaccines comprising the antigenic polypeptides and therapeutic antibodies directed to the antigenic polypeptides.

REFERENCES:
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patent: 2003/0054436 (2003-03-01), Kunsch et al.
Mikayama et al. (Nov. 1993. Proc.Natl.Acad.Sci. USA, vol. 90 : 10056-10060).
Rudinger et al. (Jun. 1976. Peptide Hormones. Biol.Council. pp. 5-7.
Murphy et al. Pediatr. Infect. Dis. J. 1989. 8: S66-S68.
Yamanaka et al (J. Pediatrics. 1993. 122(2): 212-218).
Greenspan et al (Nature Biotechnology 7: 936-937, 1999).
Chothia et al (The EMBO Journal, 1986, 5/4:823-26).
Accession No. Q931S5, Dec. 1, 2001.
Accession No. Q99UE3, Jun. 1, 2001.
Horsburgh et al., “PheP, a Putative Amino Acid Permease ofStaphylococcus aureus, Contributes to Survival in Vivo and during Starvation,”Infect. Immun. 72:3073-3076 (2004).
Kuroda et al., “Whole Genome Sequencing of Meticillin-ResistantStaphylococcus aureus,” Lancet357:1225-1240 (2001).

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