Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-03-14
1990-11-27
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514274, 514369, 548337, 548182, 548186, 544315, 544318, C07D23384, A61K 31415
Patent
active
049735993
ABSTRACT:
Compounds of the formula ##STR1## wherein n is a integer of 0 to 2; R.sub.1 ' and R.sub.2 ' are, independently, hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl; and X is pyrimidinyl, thiazolyl or ##STR2## wherein R is hydrogen, lower alkyl, aryl or ar-lower alkyl; provided that at least one or R.sub.1 ' and R.sub.2 ' is other than hydrogen,
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Niedballa et al., Chemical Abstracts, vol. 96, Entry 181284w (1982).
van Zwieten et al., Chemical Abstracts, vol. 57, Entry 12464h (1962).
van Zwieten et al., C.A. 57; 16547f (1962).
van Zwieten et al., C.A. 57: 17134(c) (1962).
Bouin-Roubaud et al., Can. J. Chem. vol. 59, pp. 2883-2890 (1981).
Delarge et al., Eur. J. Med. Chem. Chim. Ther., (1984) 19 No. 6, 559-565.
Chen Wen Y.
Gilman Norman W.
Ford John M.
Gould George M.
Hoffman-La Roche Inc.
Isgro William G.
Leon Bernard S.
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